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Fr systemische Anwendungen liegen bislang keine ausreichenden klinischen Daten vor, um eine medizinische Zulassung zu begrnden

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For instance, PGC1-related coactivators can activate the expression of NRF1, NRF2, and transcription factor A (TFAM, the final effectors of mtDNA transcription and replication) to regulate the expression of respiratory chain and the biogenesis of mitochondria, a process that has been well-documented in previous reviews (Scarpulla, 2008